Syk Inhibitor IV, BAY 61-3606 - CAS 732938-37-8 - Calbiochem,732983-37-8

别名

Syk Inhibitor IV, BAY 61-3606 - CAS 732938-37-8 - Calbiochem,2-(7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino)-nicotinamide, HCl, BAY 61-3606

储存条件

OK to freeze
desiccated (hygroscopic)
protect from light

一般描述

A cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 μM. Shown to inhibit Syk-mediated cellular functions in vitro and exhibit good oral bioavailability and in vivo effacacy in the treatment of various allgery and asthma conditions in rat models.

生化/生理作用

Cell permeable: yes Primary Target
Syk Product competes with ATP. Reversible: yes

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Yamamoto, N., et al. 2003. J. Pharm. Exp. Ther.306, 1174.