跨膜G蛋白偶联受体多肽/217082-57-0/Apelin-17 (human, bovine, mouse, rat)

Product Name：Apelin-17 (human, bovine, mouse, rat)

CAS No.：217082-57-0

Synonyms：内源性配体多肽Apelin Precursor (61-77) (human, bovine, mouse, rat)；Preproapelin (61-77) (human, bovine, mouse, rat)；[Phe17]-Apelin 17

Catalog No.：114P06

Brand：HongTide（上海鸿肽生物）

Description：Apelin是跨膜G蛋白偶联受体APJ的内源性配体，在组织中广泛分布，心血管、肾脏、神经和大脑等系统中均有表达。Apelin/APJ系统具有增强心肌收缩力，降低血压，促进血管生长，调节胰岛素的分泌，垂体激素释放及体液平衡等多种生物学效应。Apelin前体肽由77个氨基酸残基组成，随后被裂解为不同氨基酸长度的片段，包括：Apelin-12、Apelin-13、Apelin-17和Apelin-36等，这些多肽都可以通过多肽合成生产出来。研究表明Apelin-17可以促进血小板聚集以及促进体外血栓形成，同时APJ受体阻断剂F13A抑制Apelin-17诱导的血小板聚集和体外血栓形成作用。此外Apelin-17具有协同血小板激活剂凝血酶诱导的血小板聚集。

Apelin is an endogenous ligand of the transmembrane G protein coupled receptor APJ, widely distributed in tissues and expressed in cardiovascular, renal, neural, and brain systems. The Apelin/APJ system has various biological effects such as enhancing myocardial contractility, lowering blood pressure, promoting vascular growth, regulating insulin secretion, pituitary hormone release, and humoral balance. Apelin precursor peptides are composed of 77 amino acid residues, which are then cleaved into fragments of different amino acid lengths, including Apelin-12, Apelin-13, Apelin-17, and Apelin-36. These peptides can all be produced through peptide synthesis. Research has shown that Apelin-17 can promote platelet aggregation and in vitro thrombosis, while APJ receptor blocker F13A inhibits Apelin-17 induced platelet aggregation and in vitro thrombosis. In addition, Apelin-17 exhibits synergistic platelet activator thrombin induced platelet aggregation.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

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