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网站主页 RECOMBINANT HUMAN TIE2 PROTEIN Recombinant Human TIE2 protein
  • Recombinant Human TIE2 protein

Recombinant Human TIE2 protein 新品

Recombinant Human TIE2 protein
￥1950 50ug 起订
￥2890 100ug 起订
￥3760 200ug 起订
上海 更新日期：2025-01-17

上海沪震实业有限公司

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联系人：陈环环
电话：021-60345367拨打
手机：13916550749 拨打
邮箱：sales@shzbio.com

产品详情:

中文名称：
Recombinant Human TIE2 protein
英文名称：
Recombinant Human TIE2 protein
品牌：
沪震生物
产地：
中国/上海
保存条件：
-20°C
纯度规格：
> 99%
产品类别：
重组蛋白
货号：
HZ502763Q
用途范围：
Positive Control; Immunogen; SDS-PAGE; WB
规格：
10ug 50ug 100ug 200ug 1mg

Recombinant Human TIE2 protein

Product Name:Recombinant Human TIE2 protein
Cat No.:HZ502763Q
TargetID:Q02763
Source:E.coli
Gene Accession Number:7010
Peptide Sequence:Met1-Ile465
Tag:N-6His
Purity:> 80%
Formulation:20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Storage Buffer:20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Storage Condition:Aliquot and store at -20¡ãC to -80¡ãC for up to 6 months, buffer containing 7686% glycerol is recomm
Category:Protein
Species Reactivity:Human
Predicted Molecular Mass:55.1kDa
Applications:Positive Control; Immunogen; SDS-PAGE; WB
Background:Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of pro-inflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1; SHC1 and TIE1.
Size:10ug  50ug  100ug  200ug  1mg
Synonyms:CD202b; CD202-B; TEK; VMCM1; Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 2; Venous

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仅供科研使用。不能用于人和动物治疗等其它临床诊断用！

CD202b;CD202-B;TEK;VMCM1;Tyrosine ;Kinase;With ;Immunoglobulin ;

公司简介

上海沪震实业有限公司是一家集研发、生产和销售于一体的生命科学实验室产品生物科技企业。主营产品：试剂盒，ELISA试剂盒，抗体，重组蛋白，血清，胎牛血清，细胞，原代细胞 细胞培养试剂，常用生化试剂。

成立日期 (11年)
注册资本 100万元整
员工人数 10-50人
年营业额 ￥ 100万以内
经营模式 工厂,试剂,定制,服务
主营行业 生化试剂,细胞培养,蛋白组学,分子生物学,细胞生物学

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