Anti-Phospho-LATS1 (Ser909) antibody-磷酸化肿瘤抑制基因LATS1抗体

Rabbit  Anti-Phospho-LATS1 (Ser909) Polyclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:Phospho-LATS1 (Ser909)

IR:Immunogen Range:AH(p-S)LV

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:9113

Swiss Prot:O95835

Source:KLH conjugated synthesised phosphopeptide derived from human LATS1 around the phosphorylation site of Ser909:AH(p-S)LV 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq].

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Pig
Cow
Horse
Rabbit

仅供科研使用。不能用于人和动物治疗等其它临床诊断用！