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网站主页 磷酸化酪氨酸蛋白激酶BTK重组兔单克隆抗体 Anti-Phospho-BTK (Tyr223) antibody-磷酸化酪氨酸蛋白激酶BTK重组兔单抗
  • Anti-Phospho-BTK (Tyr223) antibody-磷酸化酪氨酸蛋白激酶BTK重组兔单抗

Anti-Phospho-BTK (Tyr223) antibody-磷酸化酪氨酸蛋白激酶BTK重组兔单抗

Phospho-BTK (Tyr223)
1580 50ul 起订
2680 100ul 起订
上海 更新日期:2024-11-01

上海沪震实业有限公司

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联系人:陈环环
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产品详情:

中文名称:
Anti-Phospho-BTK (Tyr223) antibody-磷酸化酪氨酸蛋白激酶BTK重组兔单抗
英文名称:
Phospho-BTK (Tyr223)
品牌:
沪震生物
产地:
中国/上海
保存条件:
-20°C
纯度规格:
> 99%
产品类别:
抗体 一抗
抗体名:
BTK(Y223); BTK (phospho Y223); p-BTK (phospho Y223); Agammaglobulinaemia tyrosine kinase; AGMX 1; AGMX1; AT; ATK; B cell progenitor kinase; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; Bruton’s Tyrosine Kinase; Btk; BTK_HUMAN; IMD 1; IMD1; MGC126261; MGC126262; OTTHUMP00000063593; PSCTK 1; PSCTK1; Tyrosine protein kinase BTK; Tyrosine-protein kinase BTK; XLA.
靶点:
详见说明书
宿主:
Rabbit
适应物种:
详见说明书
克隆性:
详见说明书
浓度:
1mg/ml
应用范围:
WB=1:1000-2000 IHC-P=1:100-500 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
标识物:
详见说明书
形态:
液体
亚型:
IgG
免疫原:
详见说明书
货号:
Hz-R52136
用途范围:
科研使用
规格:
50ul/100ul
是否进口:
是否单克隆:
详见说明书
保质期:
12个月
抗原来源:
详见说明书
标记物:
详见说明书
产品用途:
WB=1:1000-2000 IHC-P=1:100-500 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

Rabbit  Anti-Phospho-BTK (Tyr223) Monoclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:Phospho-BTK (Tyr223)

IR:Immunogen Range:AL(p-Y)DY

Clonality:Monoclonal

Isotype:IgG

Entrez Gene:695

Swiss Prot:Q06187

Source:KLH conjugated Synthesised phosphopeptide derived from human Btk around the phosphorylation site of Tyr223:AL(p-Y)DY 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.

Size:50ul

Concentration:1mg/ml

Applications:WB(1:1000-2000)
IHC-P(1:100-500)
IHC-F(1:50-200)
ICC(1:50-200)
IF(1:50-200)

Cross Reactive Species:Human
Mouse
Rat


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"仅供科研使用。不能用于人和动物治疗等其它临床诊断用!

Phospho-BTK (Tyr223);BTK(Y223);BTK (phospho Y223); p-BTK (phospho Y223;AGMX 1;AGMX1;ATK;MGC126261;

公司简介

上海沪震实业有限公司是一家集研发、生产和销售于一体的生命科学实验室产品生物科技企业。主营产品:试剂盒,ELISA试剂盒,抗体,重组蛋白,血清,胎牛血清,细胞,原代细胞 细胞培养试剂,常用生化试剂。

成立日期 (11年)
注册资本 100万元整
员工人数 10-50人
年营业额 ¥ 100万以内
经营模式 工厂,试剂,定制,服务
主营行业 生化试剂,细胞培养,蛋白组学,分子生物学,细胞生物学

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