Anti-AKT antibody-蛋白激酶B单克隆抗体

Mouse  Anti-AKT Monoclonal Antibody
DATASHEET

Host:Mouse

Target Protein:AKT

IR:Immunogen Range:420-479/479

Clonality:Monoclonal

Isotype:IgG

Entrez Gene:207

Swiss Prot:P31749

Source:KLH conjugated synthetic peptide derived from human AKT:420-479/479 

Purification:affinity purified by Protein G

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-1000)
ELISA(1:5000-10000)
ICC(1:100)

Cross Reactive Species:Human
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仅供科研使用。不能用于人和动物治疗等其它临床诊断用！