Anti-ATP6V0D2 antibody-ATP6V0D2蛋白抗体

Rabbit  Anti-ATP6V0D2 Polyclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:ATP6V0D2

IR:Immunogen Range:251-350/350

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:245972

Swiss Prot:Q8N8Y2

Source:KLH conjugated synthetic peptide derived from human ATP6V0D2/V-ATPase D2:251-350/350 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Vacuolar-type H+-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, while F-ATPases reverse the process, thereby synthesizing ATP. A peripheral V1 domain, which is responsible for ATP hydrolysis, and a integral V0 domain, which is responsible for proton translocation, compose V-ATPase. Nine subunits (A–H) make up the V1 domain and five subunits (a, d, c, c' and c") make up the V0 domain. Like F-ATPase, V-ATPase most likely operates through a rotary mechanism. V-ATPase D2 is a 350 amino acid protein that is expressed in kidney, lung and osteoclast. V-ATPase D2 has been implicated as a regulator of urine acidification, osteoclast fusion and bone formation. Furthermore, V-ATPase D2 has been identified as a dendritic cell marker.

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)

Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Sheep

仅供科研使用。不能用于人和动物治疗等其它临床诊断用