Anti-Phospho-ACACA (Ser79) antibody-磷酸化乙酰辅酶A羧化酶1ACCα抗体 新品

Rabbit  Anti-Phospho-ACACA (Ser79) Polyclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:Phospho-ACACA (Ser79)

IR:Immunogen Range:SM(p-S)GL

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:107476

Swiss Prot:Q5SWU9

Source:KLH conjugated synthesised phosphopeptide derived from mouse Acetyl Coenzyme A Carboxylase around the phosphorylation site of Ser79:SM(p-S)GL 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACC alpha (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACC∫ (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACC alpha is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the enzyme’s short-term regulatory mechanism. The gene encoding ACC alpha maps to human chromosome 17 and encodes a form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACC∫ is homologous to that of the ACCå, except for an additional peptide of about 150 amino acids at the N-terminus.

Size:50ul

Concentration:1mg/ml

Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Horse
Sheep
Guinea Pig

仅供科研使用。不能用于人和动物治疗等其它临床诊断用！