Anti-phospho-NCF1 (Ser359) antibody-磷酸化嗜中性粒细胞胞浆因子1抗体

Rabbit  Anti-phospho-NCF1 (Ser359) Polyclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:phospho-NCF1 (Ser359)

IR:Immunogen Range:QR(p-S)K

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:653361

Swiss Prot:P14598

Source:KLH conjugated synthesised phosphopeptide derived from human NCF1 around the phosphorylation site of Ser359:QR(p-S)K 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:The heredity chronic granulomatous disease (CGF) has been linked to mutations in p47-phox and p67-phox. The cytosolic proteins p47-phox and p67-phox, also designated neutrophil cytosol factor (NCF)1 and NCF2, respectively, are required for activation of the superoxide-producing NADPH oxidase in neutrophils and other phagocytic cells. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with cytochrome b558 and the small G protein Rac to form the functional enzyme complex. Both p47-phox and p67-phox contain two Src homology 3 (SH3) domains. The C-terminal SH3 domain of p67-phox has been shown to interact with the proline-rich domain of p47-phox, suggesting that p47-phox may faciliate the transport of p67-phox to the membrane.

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)

Cross Reactive Species:Human
Rat

仅供科研使用。不能用于人和动物治疗等其它临床诊断用！