Anti-EDA2R antibody-肿瘤坏死因子受体超家族成员27抗体

Rabbit  Anti-EDA2R Polyclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:EDA2R

IR:Immunogen Range:51-150/297

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:60401

Swiss Prot:Q9HAV5

Source:KLH conjugated synthetic peptide derived from human EDA2R/TNFRSF27:51-150/297 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:The tumor necrosis factor receptor (TNFR) superfamily represents a growing family of type I transmembrane glycoproteins that are involved in various cellular functions, including proliferation, differentiation and programmed cell death (1–3). These proteins share homology for cysteine-rich repeats in the extracellular ligand binding domain and an intracellular death domain (1–3). Members of the TNFR superfamily transmit signals through protein-protein interactions, and these signals can lead to the activation of either the caspase and Jun kinase pathways, which promote cell death, or the NFkB pathway, which results in cell survival (1). The ectodermal dysplasia receptor (EDAR) promotes all three of these pathways and mediates ectodermal differentiation (4). EDAR is encoded by the downless gene and is mutated in ectodermal dysplasia syndromes, which are characterized by impaired hair, teeth and sweat gland development (5). Ectodysplasin A (EDA) is a type II membrane protein that is encoded by the Tabby gene and produces many splice variants, the longest of which, EDA-A1, serves as the ligand for EDAR (5–7). EDA-A2, which differs from EDA-A1 by the deletion of two amino acids, binds only the X-linked ectodysplasin-A2 receptor (XEDAR) (7). Both EDAR and XEDAR exhibit homology with TROY (8).

Size:50ul

Concentration:1mg/ml

Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat

仅供科研使用。不能用于人和动物治疗等其它临床诊断用！