抑制剂多肽BK-1361/1975145-82-4/BK-1361(cyclo(RLsKDK))

Product Name：BK-1361(cyclo(RLsKDK))

CAS No.：1975145-82-4

Synonyms：抑制剂多肽BK-1361；BK1361；cyclo-RLsKDK)

Catalog No.：218P424

Brand：HongTide（上海鸿肽生物）

Description：BK-1361(cyclo(RLsKDK))是一种由6个氨基酸组成的环肽，其中含好一个D型氨基酸,其作为ADAM8的有效选择性抑制剂起作用，IC50为120nM；BK-1361(cyclo(RLsKDK))对ADAM 9,10,12没有显示出显着活性。BK-1361(cyclo(RLsKDK))在基于细胞的脱落测定中抑制CD23的脱落,IC50为182nM,减少胰腺癌细胞的迁移/侵袭,减少ERK1/2和MMP活化,引起细胞形态的变化；同时减少肿瘤负荷和植入的胰腺肿瘤细胞的转移,并提供Kras(G12D)驱动的临床症状和存活的改善指标PDAC的小鼠模型。

BK-1361 (cycli (RLsKDK)) is a cyclic peptide composed of six amino acids, which contains a D-type amino acid. It acts as an effective selective inhibitor of ADAM8, with an IC50 of 120 nM; BK-1361 (cycle (RLsKDK)) did not show significant activity against ADAM 9,10,12. BK-1361 (cycli (RLsKDK)) inhibits CD23 shedding in cell-based shedding assay, IC50 is 182 nM, reduces migration/invasion of pancreatic cancer cells, reduces ERK1/2 and MMP activation, and causes changes in cell morphology; A mouse model of PDAC that simultaneously reduces tumor burden and metastasis of implanted pancreatic tumor cells, and provides clinical symptom and survival improvement indicators driven by Kras (G12D).

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

Sequence(1-letter code)	cyclo(RL{d-S}KDK)
Sequence(3-letter code)	cyclo(Arg-Leu-D-Ser-Lys-Asp-Lys)
Peptide Structure
Molecular Formula	C31H57N11O9
Molecular Weight	727.86

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