Anti-Thrombin heavy chain antibody-凝血酶(凝血因子II)重链抗体

Rabbit  Anti-Thrombin heavy chain Polyclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:Thrombin heavy chain

IR:Immunogen Range:551-622/622

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:2147

Swiss Prot:P00734

Source:KLH conjugated synthetic peptide derived from human Thrombin heavy chain:551-622/622 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Thrombin is the final protease in the blood coagulation cascade and serves both pro- and anticoagulant functions through the cleavage of several targets. The ability of thrombin to specifically recognize a wide range of substrates derives from interactions which occur outside of the active site of thrombin. Thrombin possesses two anion binding exosites which mediate many of its interactions with cofactors and substrates, and although many structures of thrombin have been solved, few such interactions have been described in molecular detail. Glycosaminoglycan binding to exosite II of thrombin plays a major role in switching off the procoagulant functions of thrombin by mediating its irreversible inhibition by circulating serpins and by its binding to the endothelial cell surface receptor thrombomodulin.

Size:50ul

Concentration:1mg/ml

Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat
Chicken
Pig
Cow
Horse
Rabbit
Fish

仅供科研使用。不能用于人和动物治疗等其它临床诊断用！