Anti-ER36 antibody-雌激素受体α36抗体

Rabbit  Anti-ER36 Polyclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:ER36

IR:Immunogen Range:271-310/312

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:2099

Swiss Prot:P03372-4

Source:KLH conjugated synthetic peptide derived from human ER36:271-310/312 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER Alpha and ER Beta. ER Alpha and ER Beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors.

Size:50ul

Concentration:1mg/1ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)

Cross Reactive Species:Human
Mouse

仅供科研使用。不能用于人和动物治疗等其它临床诊断用！