Anti-GRM1 + GRM5 antibody-促代谢型谷氨酸受体1+5抗体 新品

Rabbit  Anti-GRM1 + GRM5 Polyclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:GRM1 + GRM5

IR:Immunogen Range:501-600/1194

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:2911

Swiss Prot:Q13255

Source:KLH conjugated synthetic peptide derived from human MGLUR1 + MGLUR5:501-600/1194 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include Metabotropic Glutamate Receptor 5 and Metabotropic Glutamate Receptor 1a. The Group-II receptors in include mGluR2 and mGluR3.

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)

Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Pig
Cow
Horse
Sheep

仅供科研使用。不能用于人和动物治疗等其它临床诊断用！