Anti-phospho-IRS1 (Ser312) antibody-磷酸化胰岛素受体底物-1抗体 新品

Rabbit  Anti-phospho-IRS1 (Ser312) Polyclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:phospho-IRS1 (Ser312)

IR:Immunogen Range:AT(p-S)PA

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:3667

Swiss Prot:P35568

Source:KLH conjugated Synthesised phosphopeptide derived from human IRS1 around the phosphorylation site of Ser312:AT(p-S)PA 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed.

Size:50ul

Concentration:1mg/ml

Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
Flow-Cyt(0.2μg/Test)

Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Horse
Rabbit
Sheep

仅供科研使用。不能用于人和动物治疗等其它临床诊断用！