Anti-Phospho-Jak1 (Tyr1034 + Tyr1035) antibody-磷酸化蛋白质酪氨酸激酶JAK-1抗体

Rabbit  Anti-Phospho-Jak1 (Tyr1034 + Tyr1035) Polyclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:Phospho-Jak1 (Tyr1034 + Tyr1035)

IR:Immunogen Range:KE(p-Y)(p-Y)TV

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:3716

Swiss Prot:P23458

Source:KLH conjugated Synthesised phosphopeptide derived from human Jak1 around the phosphorylation site of Tyr1034 + Tyr1035:KE(p-Y)(p-Y)TV 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Janus kinase 1 (JAK1) is a member of a new class of non-receptor protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Flow-Cyt(2μg /Test)

Cross Reactive Species:Human
Mouse
Rat
Pig
Cow

仅供科研使用。不能用于人和动物治疗等其它临床诊断用！