Anti-Phospho-Smad1/5 (Ser463 + Ser465) antibody-磷酸化细胞信号转导分子Smad-1/5抗体

Rabbit  Anti-Phospho-Smad1/5 (Ser463 + Ser465) Polyclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:Phospho-Smad1/5 (Ser463 + Ser465)

IR:Immunogen Range:IS(p-S)V(p-S)

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:4086

Swiss Prot:Q15797

Source:KLH conjugated Synthesised phosphopeptide derived from human Smad1/5 around the phosphorylation site of Ser463/465:IS(p-S)V(p-S) 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq].

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat

仅供科研使用。不能用于人和动物治疗等其它临床诊断用！