Anti-phospho-ASK1 (Ser966) antibody-磷酸化细胞凋亡信号调节激酶1抗体

Rabbit  Anti-phospho-ASK1 (Ser966) Polyclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:phospho-ASK1 (Ser966)

IR:Immunogen Range:SI(p-S)LP

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:4217

Swiss Prot:Q99683

Source:KLH conjugated Synthesised phosphopeptide derived from human ASK1 around the phosphorylation site of Ser966:SI(p-S)LP 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)

Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Horse

仅供科研使用。不能用于人和动物治疗等其它临床诊断用！