Anti-PLCZ1 antibody-磷酸肌醇磷脂酶PLCZ1抗体

Rabbit  Anti-PLCZ1 Polyclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:

Host:Rabbit

Target Protein:PLCZ1

IR:Immunogen Range:351-450/608

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:89869

Swiss Prot:Q86YW0

Source:KLH conjugated synthetic peptide derived from human PLCZ1:351-450/608 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, PLCZ1 hydrolyzes PtdIns(4,5)P2 in a Ca2+-dependent manner. It triggers intracellular Ca2+ oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. PLCZ1 is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. It may exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.

Size:50ul

Concentration:1mg/ml

Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Horse

仅供科研使用。不能用于人和动物治疗等其它临床诊断用！