Anti-CTNND2/delta 2 Catenin antibody-δ-连环蛋白抗体

Rabbit  Anti-CTNND2/delta 2 Catenin Polyclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:CTNND2/delta 2 Catenin

IR:Immunogen Range:111-210/1225

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:1501

Swiss Prot:Q9UQB3

Source:KLH conjugated synthetic peptide derived from human CTNND2/delta 2 Catenin:111-210/1225 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:The Alpha-, Beta-, Gamma-, and Delta -catenins are proteins that bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. Alpha-catenin interacts with E-cadherin associated protein and also associates with other members of the cadherin family, such as N-cadherin and P-cadherin. Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. Beta-catenin also complexes with the tumor suppressor protein APC. Gamma-catenin, also known as plakoglobin, is a protein that binds ?catenin and N-cadherin. Gamma-catenin interacts with presenilin 1 and is expressed in the brain. The gene encoding Gamma-catenin maps to human chromosome 5p15.2. A hemizygous loss of the gene encoding Gamma-catenin leads to the mental retardation associated with Cri-du-Chat syndrome. In addition, the transmembrane phosphatase PTPm associates with catenin/ cadherin complexes and may regulate complex signaling.

Size:50ul

Concentration:1mg/ml

Applications:IHC-P(1:100-500)

Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Sheep

仅供科研使用。不能用于人和动物治疗等其它临床诊断用！