Anti-CRTC1 antibody-环腺苷酸应答元件结合蛋白转录共激活因子TORC1抗体

Rabbit  Anti-CRTC1 Polyclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:CRTC1

IR:Immunogen Range:3-100/634

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:23373

Swiss Prot:Q6UUV9

Source:KLH conjugated synthetic peptide derived from human CRTC1:3-100/634 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11;19) (q21;p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein.

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(2μg /Test)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
RatChicken
Dog
Cow

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本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用！