Anti-HPV16 E7 antibody -人乳头瘤病毒16型E7抗体

Rabbit  Anti-HPV16 E7 Polyclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:HPV16 E7

IR:Immunogen Range:41-90/98

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:1489079

Swiss Prot:P03129

Source:KLH conjugated synthetic peptide derived from HPV16 E7 protein:41-90/98 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.

Size:50ul

Concentration:1mg/ml

Applications:IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(1ug/Test)
IF(1:100-500)

Cross Reactive Species:.

本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用！