CD95/FAS 载脂蛋白1抗体

Rabbit  Anti-CD95/FAS Polyclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:CD95/FAS

IR:Immunogen Range:81-170/335

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:355

Swiss Prot:P25445

Source:KLH conjugated synthetic peptide derived from human FAS/Apo-1/CD95:81-170/335 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Flow-Cyt(2μg/Test)

Cross Reactive Species:Human
Mouse
Rat
Pig

本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用！