VSIG4 T淋巴细胞负调节蛋白抗体

Rabbit  Anti-VSIG4 Polyclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:VSIG4

IR:Immunogen Range:81-160/399

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:11326

Swiss Prot:Q9Y279

Source:KLH conjugated synthetic peptide derived from human VSIG4:81-160/399 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:T cell activation by APCs is positively and negatively regulated by members of the B7 family. We have identified a previously unknown function for B7 familyrelated protein V-set and Ig domaincontaining 4 (VSIG4). Administration to mice of soluble VSIG4-Ig fusion molecules reduced the induction of T cell responses in vivo and inhibited the production of Th celldependent IgG responses. Unlike that of B7 family members, surface expression of VSIG4 was restricted to resting tissue macrophages and absent upon activation by LPS or in autoimmune inflammatory foci. The specific expression of VSIG4 on resting macrophages in tissue suggests that this inhibitory ligand may be important for the maintenance of T cell unresponsiveness in healthy tissues.

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat
Dog
Cow

本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用！