α-KTx3 毒素多肽/183815-75-0/OSK-1

Product Name：OSK-1

CAS No.：183815-75-0

Synonyms：α-KTx3 毒素多肽

Catalog No.：218P364

Brand：HongTide（上海鸿肽生物）

Description：OSK-1是有效的Kv通道阻断剂多肽，序列中含有38个氨基酸，并且包含3对二硫键，OSK-1对 Kv1.1、Kv1.2、Kv1.3 的 IC50 分别为 0.6 nM、5.4 nM、0.014 nM。OSK1是 Ca2+ 激活的 KCa3.1 通道的中度阻滞剂，IC50 为 225 nM。OSK-1 属于 α-KTx3 毒素，有潜力用作免疫抑制活性分子。

OSK-1 is an effective Kv channel blocker peptide with a sequence of 38 amino acids and 3 pairs of disulfide bonds. OSK-1 has an IC50 of 0.6 nM, 5.4 nM, and 0.014 nM for Kv1.1, Kv1.2, and Kv1.3, respectively. OSK1 is a moderate blocker of Ca2+activated KCa3.1 channel, with an IC50 of 225 nM. OSK-1 belongs to α- KTx3 toxin has the potential to be used as an immunosuppressive active molecule.

Purity (HPLC) ≥75.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

Sequence(1-letter code)	GVIINVKCKISRQCLEPCKKAGMRFGKCMNGKCHCTPK(Disulfide bridge:Cys8-Cys28,Cys14-Cys33,Cys18-Cys35)
Sequence(3-letter code)	H-Gly-Val-Ile-Ile-Asn-Val-Lys-Cys-Lys-Ile-Ser-Arg-Gln-Cys-Leu-Glu-Pro-Cys-Lys-Lys-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys-Met-Asn-Gly-Lys-Cys-His-Cys-Thr-Pro-Lys-OH(Disulfide bridge:Cys8-Cys28,Cys14-Cys33,Cys18-Cys35)
Peptide Structure
Molecular Formula	C177H300N56O46S8
Molecular Weight	4205.17

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