Anti-Phospho-Estrogen Receptor alpha antibody-磷酸化雌激素受体α抗体

Host:Rabbit

Target Protein:Phospho-Estrogen Receptor alpha (Ser118)

IR:Immunogen Range:QL(p-S)PF

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:2099

Swiss Prot:P03372

Source:KLH conjugated Synthesised phosphopeptide derived from human ER alpha around the phosphorylation site of Ser118:QL(p-S)PF 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. ER alpha and ER beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors.

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(1μg /Test)
ICC(1:100)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat
Pig
Rabbit

                                                                                                                                                                                                                                                                                                                          本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用！