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网站主页 phospho-GSK-3 Beta (Ser21) Anti-phospho-GSK3 Alpha + Beta antibody-磷酸化糖原合酶激酶3α/β抗体
  • Anti-phospho-GSK3 Alpha + Beta antibody-磷酸化糖原合酶激酶3α/β抗体

Anti-phospho-GSK3 Alpha + Beta antibody-磷酸化糖原合酶激酶3α/β抗体

phospho-GSK3 Alpha + Beta (Tyr279+Tyr216)
1280 50ul 起订
1980 100ul 起订
2900 200ul 起订
上海 更新日期:2024-11-07

上海沪震实业有限公司

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电话:021-60345367拨打
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产品详情:

中文名称:
Anti-phospho-GSK3 Alpha + Beta antibody-磷酸化糖原合酶激酶3α/β抗体
英文名称:
phospho-GSK3 Alpha + Beta (Tyr279+Tyr216)
品牌:
沪震生物
产地:
中国/上海
保存条件:
-20°C
纯度规格:
> 99%
产品类别:
抗体 一抗
抗体名:
GSK3B(Phospho-Tyr279+Tyr216); GSK3B(Phospho-Y279/Y216); p-GSK-3 Beta(Tyr279+Tyr216); p-GSK-3 beta(Y279/Y216); Glycogen synthase kinase 3 beta; GSK 3 beta; GSK 3B; GSK3B; GSK3B protein; GSK3beta isoform; GSK3 beta; Glycogen synthase kinase-3 beta; GSK-3 beta; Glycogen synthase kinase-3 alpha; GSK3A; GSK-3 alpha; Serine/threonine-protein kinase GSK3A; GSK3A_HUMAN; GSK3B_HUMAN. GSK 3β; GSK 3 β; GSK-3β; GSK3β; GSK 3α; GSK 3 α; GSK-3α; GSK3α;
靶点:
详见说明书
宿主:
Rabbit
适应物种:
详见说明书
克隆性:
详见说明书
浓度:
1mg/ml
应用范围:
WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
标识物:
详见说明书
形态:
液体
亚型:
IgG1
免疫原:
详见说明书
货号:
Hz-R2670
用途范围:
科研使用
规格:
50ul/100ul/200ul
是否进口:
是否单克隆:
详见说明书p55
保质期:
12个月3
抗原来源:
详见说明书
标记物:
详见说明书
产品用途:
WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

Host:Rabbit

Target Protein:phospho-GSK3 Alpha + Beta (Tyr279+Tyr216)

IR:Immunogen Range:VS(p-Y)IC

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:2932

Swiss Prot:P49841

Source:KLH conjugated Synthesised phosphopeptide derived from human GSK-3 Beta around the phosphorylation site of Tyr216:VS(p-Y)IC 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Glycogen synthase kinase 3 (GSK3) is a proline directed serine threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase, a key enzyme in glycogen metabolism. Since then, it has been shown to be involved in the regulation of a diverse array of cellular functions, including protein synthesis, cell proliferation, cell differentiation, microtubule assembly/disassembly, and apoptosis. GSK3s substrate specificity is unique in that phosphorylation of substrate only occurs if a phosphoserine or phosphotyrosine is present four residues C terminal to the site of GSK phosphorylation. There exists two isoforms of GSK3, alpha and beta, and they show a high degree of amino acid homology. The two isoforms of GSK3 are strictly regulated via phosphorylation. Phosphorylation of GSK3 beta on Ser9 (Ser21 in GSK3 alpha) by protein kinase B (PKB) causes its inactivation is the primary mechanism responsible for growth factor inhibition of this kinase. Activation of GSK3 beta is dependent upon the phosphorylation of Tyr216 (Tyr279 in GSK3 alpha). Upon activation, it has been shown to phosphorylate a number of different cellular proteins, including p53, c-Myc, c-Jun, heat shock factor 1 (HSF1), and cyclin D1. GSK3 beta also has been shown to phosphorylate aberrant sites on the microtubule associated protein tau, which is critical for the progression of Alzheimer's disease. GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation.

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(1μg /test)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Pig
Cow
Horse
Rabbit
Sheep
Guinea Pig

image.png                                                                                                                                             本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用!

GSK3β;GSK 3β;GSK3-β;GSK 3 β;GSK3B;GSK3B_HUMAN;GSK3α;GSK-3α;

公司简介

上海沪震实业有限公司是一家集研发、生产和销售于一体的生命科学实验室产品生物科技企业。主营产品:试剂盒,ELISA试剂盒,抗体,重组蛋白,血清,胎牛血清,细胞,原代细胞 细胞培养试剂,常用生化试剂。

成立日期 (11年)
注册资本 100万元整
员工人数 10-50人
年营业额 ¥ 100万以内
经营模式 工厂,试剂,定制,服务
主营行业 生化试剂,细胞培养,蛋白组学,分子生物学,细胞生物学

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