Product Name：μ-conotoxin PIIIA
CAS No.：N/A
Synonyms：μ-芋螺毒素mu-conotoxin PIIIA
Catalog No.：218P262
Brand：HongTide（上海鸿肽生物）
Description：μ-conotoxin PIIIA是已从紫锥花的毒液中分离出来多肽，是一条含有22个氨基酸的环状多肽，结构中含有三队二硫键。μ-conotoxin PIIIA能结合并阻断电压门控钠通道的位点 1，这种毒素会阻断神经元钠通道 Nav1.2 (SCN2A) 和 Nav1.7 (SCN9A)。μ-conotoxin PIIIA导致小鼠和鱼的弛缓性麻痹，可阻断电压门控钠通道 (Nav)。μ-conotoxin PIIIA还可有效阻断 rNav1.2/SCN2A 和 rNav1.4/SCN4A，还适度阻断 rNav1.1/SCN1A、rNav1.3/SCN3A、rNav1.5/SCN5A 和 mNav1.6/SCN8A。μ-conotoxin PIIIA的抑制是可逆的。
μ- Conotoxin PIIIA is a peptide that has been isolated from the venom of Echinacea purpurea. It is a cyclic peptide containing 22 amino acids and contains three disulfide bonds in its structure. μ- Conotoxin PIIIA can bind and block site 1 of voltage gated sodium channels, and this toxin can block neuronal sodium channels Nav1.2 (SCN2A) and Nav1.7 (SCN9A). μ- Conotoxin PIIIA causes flaccid paralysis in mice and fish, which can block the voltage gated sodium channel (Nav). μ- Conotoxin PIIIA can also effectively block rNav1.2/SCN2A and rNav1.4/SCN4A, and moderately block rNav1.1/SCN1A, rNav1.3/SCN3A, rNav1.5/SCN5A, and mNav1.6/SCN8A. μ- The inhibition of conotoxin PIIIA is reversible.
Purity (HPLC) ≥95.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | Pyr-RLCCGF-Hyp-KSCRSRQCK-Hyp-HRCC-NH2(Disulfide bridge：Cys4-Cys16;Cys5-Cys21;Cys11-Cys22) |
Sequence(3-letter code) | Pyr-Arg-Leu-Cys-Cys-Gly-Phe-Hyp-Lys-Ser-Cys-Arg-Ser-Arg-Gln-Cys-Lys-Hyp-His-Arg-Cys-Cys-NH2(Disulfide bridge：Cys4-Cys16;Cys5-Cys21;Cys11-Cys22) |
Peptide Structure | 
|
Molecular Formula | C103H166N40O28S6 |
Molecular Weight | 2605.07 |
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