Anti-HIF 2 alpha antibody -缺氧诱导因子2α /EPAS1抗体

Host:Rabbit

Target Protein:HIF 2 alpha

IR:Immunogen Range:1-130/874

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:13819

Swiss Prot:P97481

Source:KLH conjugated synthetic peptide derived from mouse HIF 2 Alpha:1-130/874 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(1µg/Test)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat
Pig
Cow
Horse

                                                                                                                                                        本产品仅供科研使用。不能用于人和动物治疗等其它临床诊断使用！