Ras抑制肽/159088-48-9/Ras Inhibitory Peptide

Product Name：Ras Inhibitory Peptide

CAS No.：159088-48-9

Synonyms：Ras抑制肽

Catalog No.：218P185

Brand：HongTide（上海鸿肽生物）

Description：Ras Inhibitory Peptide是一种抑制剂多肽，是由10个氨基酸支持的直链多肽。Son of Sevenless 同源物 1 (Sos1) 是一种鸟嘌呤核苷酸交换因子 (GEF)，通过与生长因子受体结合蛋白 2 (Grb2) 的 SH3 结构域结合，指导 Ras-GDP 与 Ras-GTP 的交换，从而导致 ERK 的激活。Ras 抑制肽是包含序列 PVPPR 的合成肽，该序列对应于人类 Sos1 中与 Grb2 的 SH3 结构域相互作用的区域，专门阻断 GEF 与 Grb2 的相互作用，防止受体酪氨酸激酶（包括表皮生长因子受体）激活 Ras 所必需的相互作用。

Ras Inhibitory Peptide is an inhibitor peptide that is a straight chain peptide supported by 10 amino acids. Son of Seven homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that binds to the SH3 domain of growth factor receptor binding protein 2 (Grb2), guiding the exchange of Ras-GDP and Ras-GTP, leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide containing the sequence PVPPR, which corresponds to the region in human Sos1 that interacts with the SH3 domain of Grb2. It specifically blocks the interaction between GEF and Grb2, preventing the necessary interactions for receptor tyrosine kinases (including epidermal growth factor receptors) to activate Ras.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

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