非选择性甘丙肽受体拮抗剂多肽/143896-17-7/M40

Product Name：M40

CAS No.：143896-17-7

Synonyms：受体拮抗剂多肽M40

Catalog No.：146P09

Brand：HongTide（上海鸿肽生物）

Description：M40是一种有效的非选择性甘丙肽受体拮抗剂多肽（GAL1和GAL2的Ki值分别为1.82和5.1nM），是由20个氨基酸组成的直链多肽，肽链中含有α-螺旋结构，可在体外抑制大鼠脑中甘丙肽(1-29)的结合（IC50 = 3）。M40能减弱氟西汀的抗抑郁作用并阻断甘丙肽诱导的体内食物摄入，当在剂量>100 nM时，外周GAL2受体也表现出微弱的部分激动剂活性。

M40 is an effective non-selective galanin receptor antagonist peptide (with Ki values of 1.82 and 5.1nM for GAL1 and GAL2, respectively). It is a straight chain peptide composed of 20 amino acids, containing α- The spiral structure can inhibit the binding of galanin (1-29) in the rat brain in vitro (IC50=3). M40 can weaken the antidepressant effect of fluoxetine and block the galanin induced food intake in vivo. When the dose is more than 100 nM, the peripheral GAL2 receptor also shows weak Partial agonist activity.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

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