Anti-Bcl-2 antibody-Bcl-2重组兔单克隆抗体

Host:Rabbit

Target Protein:Bcl-2

IR:Immunogen Range:

Clonality:Monoclonal

Isotype:IgG

Entrez Gene:596

Swiss Prot:P49950

Source:KLH conjugated synthetic peptide derived from human Bcl-2: 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:The Bcl-2 gene was isolated at the chromosomal breakpoint of t(14;18)-bearing follicular B cell lymphomas(1,2).Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal (3,5).Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer insight into its mechanism of action (6,7).A more recently identified protein,designated Bax p21(i.e., Bcl-associated X protein ),has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2(8). Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the death repressor activty of Bcl-2(8).

Size:50ul

Concentration:1mg/ml

Applications:WB(1:1000-2000)
IP(1:10-50)
IHC-P(1:50-200)
IHC-F(1:50-200)
Flow-Cyt(1:50)
ICC(1:50)
IF(1:50-200)

Cross Reactive Species:Human
Mouse

本产品仅供科研使用。不能用于人和动物治疗等其它临床诊断使用！