Product Name：Pramlintide
CAS No.： 151126-32-8；196078-30-5
Synonyms：醋酸普兰林肽
Catalog No.：215P23
Brand：HongTide（上海鸿肽生物）
Description：醋酸普兰林肽是胰淀粉样多肽（Amylin，淀粉不溶素）的一种合成类似物，是由37个氨基酸组成的环状多肽，是继胰岛素之后第二个获准用于治疗１型糖尿病的药物。在临床上，以普兰林肽为主要原料的药物，可用作１型和２型糖尿病的辅助治疗药物，主要用于单用胰岛素，以及联合应用胰岛素和磺脲类药物、二甲双胍仍无法取得预期疗效的糖尿病患者。实验证明，普兰林肽可与胰岛素合用，但不能取代胰岛素。
Pramlintide is a synthetic analog of pancreatic amyloid peptide (Amylin). It is a cyclic polypeptide composed of 37 amino acids. It is the second drug approved to treat type 1 diabetes after insulin. Clinically, the drug with Pranin as the main raw material can be used as an auxiliary treatment drug for type 1 and type 2 diabetes. It is mainly used for diabetes patients who can not achieve the expected effect with insulin alone, insulin and sulfonylurea drugs in combination, and metformin. Experiments have shown that planin can be used in combination with insulin, but it cannot replace insulin.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | KCNTATCATQRLANFLVHSSNNFGPILPPTNVGSNTY-NH2(Disulfide bridge: Cys2-Cys7) |
Sequence(3-letter code) | H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2(Disulfide bridge: Cys2-Cys7) |
Peptide Structure | 
|
Molecular Formula | C171H267N51O53S2 |
Molecular Weight | 3949.44 |
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