Caspase-3 Substrate IV, Fluorogenic Calbiochem,1177935-21-5

别名

Caspase-3 Substrate IV, Fluorogenic - CAS 1177935-21-5 - Calbiochem,Z-DEVD-AFC

一般描述

Fluorogenic CPP-32/apopain substrate. Also acts as a substrate for granzyme B-processed ICE-LAP3. Reaction can be monitored by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore. Excitation max: ~400 nm; emission max: ~505 nm. Fluorogenic caspase-3 substrate. Also acts as a substrate for granzyme B-processed ICE-LAP3. Reaction can be monitored by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore. Also a substrate for caspase-6, caspase-7, caspase-8, and caspase-10.

生化/生理作用

Cell permeable: no Primary Target
Fluorogenic caspase-3 substrate. Product does not compete with ATP. Reversible: no

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.

其他说明

Keramaris, E., et al. 2000. Mol. Cell Neurosci. 15, 368.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Kluck, R.M., et al. 1997. Science275, 1132.
Talanian, J., et al. 1997. J. Biol. Chem.272, 9677.
Chinnaiyan, A.M., et al. 1996. Curr. Biol.6, 897.
Nicholson, D.W., et al. 1995. Nature376, 37.