500164-74-9IP7e

产品属性：

Cas No.500164-74-9

别名 N/A

化学名 N/A

分子式 C23H22N2O4

分子量 390.4

溶解度 DMSO: 100 mM,Ethanol: 20 mM, warmed

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
IP7e is a brain-penetrant activator of nuclear receptor related protein 1 (Nurr1/NR4A2) signaling (EC50 = 3.9 nM in a reporter assay).1 In vivo, IP7e (10 mg/kg) prevents spinal cord axonal loss and demyelination and decreases spinal cord macrophage and T cell infiltration in a mouse model of experimental autoimmune encephalomyelitis (EAE).2

|1. Hintermann, S., Chiesi, M., von Krosigk, U., et al. Identification of a series of highly potent activators of the Nurr1 signaling pathway. Bioorg. Med. Chem. Lett. 17(1), 193-196 (2007).|2. Montarolo, F., Raffaele, C., Perga, S., et al. Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice. PLoS One 9(9), e108791 (2014).