152044-54-7Epothilone B (EPO906, Patupilone)

产品属性：

Cas No.152044-54-7

别名

化学名 (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione

分子式 C27H41NO6S

分子量 507.68

溶解度 ≥ 25.4mg/mL in DMSO

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Epothilone B (EPO906, Patupilone) is a naturally occurring microtubule-stabilizing macrolide that was first isolated from the myxobacterium Sorangium cellulosum. The EC0.01 value of Epothilone B is 1.8 nM [1].

Epothilone B exhibits the same mechanism of action as paclitaxel. More importantly, in cell culture, Epothilone B is active against paclitaxel-resistant cell lines that express P-glycoprotein. Furthermore, Epothilone B has better solubility in water than paclitaxel [1].

Epothilone B induced an increase in the level of the intracellular free calcium only during the longer times following the treatment in SKOV-3 cells. Besides, the ovarian cancer cells treated with Epothilone B showed a time course dependent increase in the cytosolic fraction of cytochrome c [2].

References:

[1] Regueiro-Ren A1, Borzilleri RM, Zheng X, Kim SH, Johnson JA, Fairchild CR, Lee FY, Long BH, Vite GD. Synthesis and biological activity of novel epothilone aziridines. Org Lett. 2001 Aug 23;3(17):2693-6.

[2] Rogalska A1, Gajek A2, Marczak A2. Epothilone B induces extrinsic pathway of apoptosis in human SKOV-3 ovarian cancer cells. Toxicol In Vitro. 2014 Jun;28(4):675-83.