72389-06-1Aranciamycin

产品属性：

Cas No.72389-06-1

别名 N/A

化学名 N/A

分子式 C27H28O12

分子量 544.5

溶解度 Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Aranciamycin is a fungal metabolite that has been found in Streptomyces and has diverse biological activities.1,2 It inhibits C. histolyticum collagenase but not elastase or trypsin in cell-free assays (IC50s = 0.37, >10, and >10 µM, respectively).1 Aranciamycin is active against M. bovis and B. subtilis (MICs = 30 and 15 µM, respectively).2 It is cytotoxic to HepG2 cells (IC50 = 18 µM).

1.Bols, M., Biderup, L., Hansen, J., et al.Inhibition of collagenase by aranciamycin and aranciamycin derivativesJ. Med. Chem.35(15)1768-2771(1992) 2.Khalil, Z.G., Raju, R., Piggott, A.M., et al.Aranciamycins I and J, antimycobacterial anthracyclines from an Australian marine-derived Streptomyces spJ. Nat. Prod.78(4)949-952(2015)