76455-48-64-bromo A23187

产品属性：

Cas No.76455-48-6

别名 4-Bromocalcimycin

化学名 6-bromo-5-(methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid

分子式 C29H36BrN3O6

分子量 602.5

溶解度 1mg/mL in DMSO, 10mg/mL in DMF

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
4-bromo A23187 is a halogenated analog of the highly selective calcium ionophore A23187. 4-bromo A23187 is non-fluorescent.[1] As a result, it is often used in experiments where fluorescent probes are employed.[2],[3]

Reference:

[1]. Deber, C.M., Tom-Kun, J., Mack, E., et al. Bromo-A23187: A nonfluorescent calcium ionophore for use with fluorescent probes. Anal.Biochem. 146(2), 349-352 (1985).

[2]. Ducreux, S., Gregory, P., and Schwaller, B. Inverse regulation of the cytosolic Ca2+ buffer parvalbumin and mitochondrial volume in muscle cells via SIRT1/PGC-1α axis. PLoS One 7(9), (2012).

[3]. Yang, J., Singh, V., Cha, B., et al. NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells. J.Biol.Chem. 288(23), 16960-16974 (2013).