178603-78-6Ac-YVAD-CMK

产品属性：

Cas No.178603-78-6

别名 N/A

化学名 N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxo-propyl]-L-alaninamide

分子式 C24H33ClN4O8

分子量 541

溶解度 20mg/mL in DMSO, 10mg/mL in DMF

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Ac-YVAD-CMK is a selective, irreversible inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1). Ac-YVAD-CMK is neuroprotective in a rat model of cerebral ischemia.[1]

Reference:

[1]. Rabuffetti, M., Sciorati, C., Tarozzo, G., et al. Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines. Journal of Neuroscience 20, 4398-4404 (2000).