15071-56-45-Methoxycanthinone

产品属性：

Cas No.15071-56-4

别名 N/A

化学名 N/A

分子式 C15H10N2O2

分子量 250.3

溶解度

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
5-Methoxycanthinone is an alkaloid that has been found in L. floridana and has anticancer properties.1 It is cytotoxic to KB, A549, and HCT-8 cells (EC50s = 2.9, 3.1, and 2.5 μg/ml, respectively). It is active against the P. falciparum mefloquine-resistant strain F32 and the multidrug and chloroquine-resistant strain K1 (IC50s = 10.4 and 5.1 μg/ml, respectively).2 However, it increases the parasite load by 68.4% in a mouse model of leishmaniasis when administered at a dose of 10 mg/kg per day.3

1.Xu, Z., Chang, F.R., Wang, H.-K., et al.Anti-HIV agents 45 and antitumor agents 205. Two new sesquiterpenes, leitneridanins A and B, and the cytotoxic and anti-HIV principles from Leitneria floridanaJ. Nat. Prod.63(12)1712-1715(2000) 2.Cebrián-Torrejón, G., Spelman, K., Leblanc, K., et al.The antiplasmodium effects of a traditional South American remedy: Zanthoxylum chiloperone var. Angustifolium against chloroquine resistant and chloroquine sensitive strains of Plasmodium falciparumRevista Brasileira de Farmacognosia21(4)652-661(2011) 3.Ferreira, M.E., Rojas de Arias, A., Torres de Ortiz, S., et al.Leishmanicidal activity of two canthin-6-one alkaloids, two major constituents of Zanthoxylum chiloperone var. angustifoliumJ. Ethnopharmacol.80(2-3)199-202(2002)