170571-01-4Celecoxib Carboxylic Acid

产品属性：

Cas No.170571-01-4

别名 N/A

化学名 N/A

分子式 C17H12F3N3O4S

分子量 411.4

溶解度 DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:6): 0.12 mg/ml,PBS (pH 7.2): slightly soluble

储存条件 Store at-20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition Evaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

Celecoxib carboxylic acid is an inactive metabolite of the COX-2 inhibitor celecoxib .1,2 It is formed from celecoxib primarily by the cytochrome P450 (CYP) isoform CYP2C9.

1.Liu, H., Huang, X., Shen, J., et al.Inhibitory mode of 1,5-diarylpyrazole derivatives against cyclooxygenase-2 and cyclooxygenase-1: Molecular docking and 3D QSAR analysesJ. Med. Chem.45(22)4816-4827(2002) 2.Kim, S.-H., Kim, D.-H., Byeon, J.-Y., et al.Effects of CYP2C9 genetic polymorphisms on the pharmacokinetics of celecoxib and its carboxylic acid metaboliteArch. Pharm. Res.40(3)382-390(2017)