产品属性：
产品名称 | 规格 | CAS号 | 型号 |
Lopinavir-d8 | 1 mg | 1322625-54-6 | EY-Y0164827 |
Cas No.1322625-54-6
别名 N/A
化学名 N/A
分子式 C37H40D8N4O5
分子量 636.9
溶解度 Chloroform: Slightly Soluble,Methanol: Slightly Soluble
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Lopinavir-d8 is intended for use as an internal standard for the quantification of lopinavir by GC- or LC-MS. Lopinavir is a potent HIV-1 protease inhibitor (Ki = 1.3 pM for wild-type enzyme).1 It inhibits the replication of clinical isolates of HIV-1 (EC50s = 5-52 nM). Lopinavir reduces the infectious virus yield and viral RNA copy numbers in the culture supernatant of Vero E6 cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; EC50s = 26.63 and 26.10 μM, respectively).2 It reduces lung and kidney viral load, bronchointerstitial pneumonia, and pulmonary inflammatory cell infiltration in a marmoset model of Middle East respiratory syndrome coronavirus (MERS-CoV) infection when administered in combination with ritonavir .3
1.Sham, H.L., Kempf, D.J., Molla, A., et al.ABT-378, a highly potent inhibitor of the human immunodeficiency virus proteaseAntimicrob. Agents Chemother.42(12)3218-3224(1998) 2.Choy, K.-T., Wong, A.-Y., Kaewpreedee, P., et al.Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitroAntiviral Res.178104786(2020) 3.Chan, J.-F., Yao, Y., Yeung, M.-L., et al.Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmosetJ. Infect. Dis.212(12)1904-1913(2015)
