1217651-73-4Colchicine-d6

产品属性：

Cas No.1217651-73-4

别名 N/A

化学名 N/A

分子式 C22H19D6NO6

分子量 405.5

溶解度 Chloroform: Slightly Soluble,Methanol: Slightly Soluble

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Colchicine-d6 is intended for use as an internal standard for the quantification of colchicine by GC- or LC-MS. Colchicine is an inhibitor of microtubule polymerization (IC50 = 3.2 μM) that binds to tubulin, which disrupts spindle formation during mitosis.1 It inhibits growth of MCF-7 human breast carcinoma cells with an IC50 value of 13 nM.1 Colchicine has anti-inflammatory activity, inhibiting neutrophil motility and activity when used at a dose of 5 μmol/kg in a mouse model of gout and preventing the deposition of uric acid.2,3

1.Martino, G.D., Regina, G.L., Coluccia, A., et al.Arylthioindoles, potent inhibitors of tubulin polymerizationJ. Med. Chem.47(25)6120-6123(2004) 2.McCarty, D.J.Urate crystals, inflammation, and colchicineArthritis Rheum.58(2)S20-S24(2008) 3.Chia, E.W., Grainger, R., and Harper, J.L.Colchicine suppresses neutrophil superoxide production in a murine model of gouty arthritis: A rationale for use of low-dose colchicineBr. J. Pharmacol.153(6)1288-1295(2008)