60-92-4Cyclic AMP

产品属性：

Cas No.60-92-4

别名 N/A

化学名 N/A

分子式 C10H12N5O6P

分子量 329.21

溶解度 insoluble in DMSO; insoluble in EtOH; >16.45 mg/mL in H2O

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Cyclic adenosine 3', 5'-monophosphate (cAMP) was the first second messenger to be identified, with the IC50 of LPA- or EGF-stimulated ERK1 was 0.1-0.2 Mm [1].

Ras is a common target for growth factors including epidermal growth factor (EGF) and lysophosphatidic acid (LPA), which activate the Raf-MEK-ERK pathway. Raf is likely to be a link between Ras and ERK cascade, of which Raf-1activates MEK in vitro.

Quiescent Rat1 cells were incubated with 1 Mm dibutyryl cAMP for 10 min before stimulation with LPA or EGF, ERK activation was completely inhibited by protein immunoblots. The ability of the phorbol ester PMA to activate MAP kinase was also inhibited by dibutyryl cAMP [1].

Reference:

[1] Cook S J, McCormick F. Inhibition by cAMP of Ras-Dependent Activation of Raf [J]. Science. 1993, 262(5136):1069-1072.