1596-64-1L-Histidinol (hydrochloride)

产品属性：

Cas No.1596-64-1

别名 (S)-Histidinol

化学名 (βS)-amino-1H-imidazole-5-propanol, dihydrochloride

分子式 C6H11N3O ? 2HCl

分子量 214.1

溶解度 ≤5mg/ml in DMSO

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
L-Histidinol is an intermediate in the biosynthesis of the amino acid L-histidine.

L-Histidine biosynthesis is a metabolic pathway present in bacteria, archaea, lower eukaryotes, as well as plants. L-histidine biosynthesis has been studied mainly in Escherichia coli and Salmonella typhimurium, revealing fundamental regulatory processes in bacteria.

In vitro: Preliminary experiments were done to investigate the cytotoxic effect of L-histidinol on cultured EAC cells. Results showed that L-histidinol up to 4 mM had no cytotoxic effects on EAC cells. Doxorubicin alone showed concentration-dependent cytotoxic effects. L-Histidinol combination with doxorubicin led to significant potentiation of doxorubicin cytotoxicity to EAC cells compared to doxorubicin alone. The concentration that caused 50% growth inhibition in EAC cells after 24 h incubation was about 0.2 μg/ml, whereas it was 0.1 μg/ml when L-histidinol was added to culture medium [1].

In vivo: L-Histidinol at 250 mg/kg for five consecutive doses before doxorubicin single injection could enhance the antitumour activity of doxorubicin in EAC-bearing mice as demonstrated by a significant increase in average life span and cure rate of mice. In normal mice, L-histidinol, in the same dose regimen, could not alter the acute cardiotoxicity and lethality of doxorubicin [1].

Clinical trial: So far, no clinical study has been conducted.

Reference:

[1] Al-Shabanah OA, Badary OA, Al-Gharably NM, Al-Sawaf HA.  Effects of L-histidinol on the antitumour activity and acute cardiotoxicity of doxorubicin in mice. Pharmacol Res. 1998 Sep;38(3):225-30.