120533-76-8BML-278

产品属性：

Cas No.120533-76-8

别名 N/A

化学名 1,4-dihydro-4-phenyl-1-(phenylmethyl)-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester

分子式 C24H25NO4

分子量 391.5

溶解度 DMF: 12.5 mg/ml,DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml,DMSO: 3 mg/ml

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 uM. It less potently activates SIRT2 and SIRT3 (EC150s = 25 and 50 uM, respectively). BML-278 induces hypoacetylation on α-tubulin in U937 cells that are pretreated with SAHA , a histone deacetylase inhibitor. It arrests cell cycling at the G1/S phase, reduces senescence in primary human mesenchymal cells, and significantly increases mitochondrial density in murine C2C12 myoblasts.