86541-78-8Benazeprilat

产品属性：

Cas No.86541-78-8

别名 CGS 14831

化学名 (3S)-3-[[(1S)-1-carboxy-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid

分子式 C22H24N2O5

分子量 396.4

溶解度 0.5mg/mL in DMSO, 0.16mg/mL in DMF

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Benazeprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 0.28 nM in plasma from dog) and the active metabolite of the prodrug benazepril. [1] Benazeprilat is produced in the liver following cleavage of the ester group from benazepril. Formulations containing the prodrug benazepril have been used to treat hypertension in human and veterinary medicine.

Reference:

[1]. Toutain, P.L., and Lefèbvre, H.P. Pharmacokinetics and pharmacokinetic/pharmacodynamic relationships for angiotensin-converting enzyme inhibitors. J. Vet. Pharmacol. Ther. 27(6), 515-525 (2004).