1012788-65-6Benzisoxazole Hsp90 Inhibitor

产品属性：

Cas No.1012788-65-6

别名 N/A

化学名 N/A

分子式 C19H20ClN3O4

分子量 389.8

溶解度 DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 25 mg/ml,Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Heat shock protein 90 (Hsp90) is a molecular chaperone that modulates intracellular signaling and protein folding, trafficking, and turnover. Inhibitors of Hsp90, such as geldanamycin, have shown promise as anti-tumor agents. Benzisoxazole Hsp90 inhibitor binds the N-terminal domain of Hsp90, efficiently displacing geldanamycin from the ATP binding site (IC50 = 30 nM). In addition, Benzisoxazole Hsp90 inhibitor inhibits the proliferation of several cancer cell lines (IC50 ~ 0.28 μM), promotes the degradation of the Hsp90 client proteins Her-2 and androgen receptor, and has no effect on a variety of kinases.