5415-44-11,3,7-Trimethyluric Acid

产品属性：

Cas No.5415-44-1

别名 8-oxo Caffeine, NSC 11259

化学名 7,9-dihydro-1,3,7-trimethyl-1H-purine-2,6,8(3H)-trione

分子式 C8H10N4O3

分子量 210.2

溶解度 DMF: 5 mg/ml,DMSO: 20 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
1,3,7-Trimethyluric acid is a methyl derivative of uric acid and a product of C-8 oxidation of caffeine by cytochrome P450 enzymes. It can be detected in urine as a marker of caffeine consumption.

Reference:

[1]. Tassaneeyakul, W., Birkett, D.J., McManus, M.E., et al. Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms. Biochem. Pharmacol. 47(10), 1767-1776 (1994).

[2]. Bhat, V.B., Sridhar, G.R., and Madyastha, K.M. Efficient scavenging of hydroxyl radicals and inhibition of lipid peroxidation by novel analogues of 1,3,7-trimethyluric acid. Life Sci. 70(4), 381-393 (2001).