38753-76-37α-Thiospironolactone

产品属性：

Cas No.38753-76-3

别名 N/A

化学名 N/A

分子式 C22H30O3S

分子量 374.5

溶解度 Ethanol: soluble

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
7α-Thiospironolactone (7α-Thio-SL) is an active metabolite of the synthetic steroid spironolactone.1 In vivo, 7α-thio-SL (100 mg/kg) decreases plasma testosterone and estradiol levels in male dogs.2 It reduces mercuric chloride-induced nephrocalcinosis and mortality in rats.3

1.Los, L.E., Coddington, A.B., Ramjit, H.G., et al.Identification of spironolactone metabolites in plasma and target organs of guinea pigsDrug Metab. Dispos.21(6)1086-1090(1993) 2.Menard, R.H., Loriaux, D.L., Bartter, F.C., et al.The effect of the administration of spironolactone on the concentration of plasma testosterone, estradiol and cortisol in male dogsSteroids31(6)771-782(1978) 3.Szabo, S., and Gagnon, M.J.The protective effect of sulfur-containing steroids against nephrocalcinosis induced by mercuric chloride in ratsGen. Pharmacol.14(2)269-272(1983)